Engineered Phage Endolysin Eliminates <i>Gardnerella</i> Biofilm Without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo

Engineered Phage Endolysin Eliminates <i>Gardnerella</i> Biofilm Without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo

Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome and a characteristic biofilm formed on the vaginal epithelium, which is initiated and dominated by <i>Gardnerella</i><i> </i>bacteria, and is frequently refractory to antibiotic treatment.<i>...

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Bibliographic Details
Main Authors: Christine Landlinger, Lenka Tisakova, Vera Oberbauer, Timo Schwebs, Abbas Muhammad, Agnieszka Latka, Leen Van Simaey, Mario Vaneechoutte, Alexander Guschin, Gregory Resch, Sonja Swidsinski, Alexander Swidsinski, Lorenzo Corsini
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Pathogens
Subjects:
bacterial vaginosis
Gardnerella biofilm
prophage
endolysin
genus-specificity
antimicrobial resistance
Online Access:https://www.mdpi.com/2076-0817/10/1/54

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https://www.mdpi.com/2076-0817/10/1/54

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