Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome[S]

Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome[S]

To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q[-2]X, were recruited together with age- and sex-matched healthy controls (n = 11). Homozygotes disp...

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Bibliographic Details
Main Authors: Fabiana Rached, Raul D. Santos, Laurent Camont, Marcio H. Miname, Marie Lhomme, Carolane Dauteuille, Sora Lecocq, Carlos V. Serrano, Jr., M. John Chapman, Anatol Kontush
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Journal of Lipid Research
Subjects:
high density lipoprotein
apolipoprotein A-I
familial deficiency
genetics
HDL functionality
cellular cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520366918

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http://www.sciencedirect.com/science/article/pii/S0022227520366918

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