Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD). Here, we sought to examine the consequences of genetic deletion of CatD on A...

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Bibliographic Details
Main Authors: Caitlin N. Suire, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Monica K. Brizuela, Paul Saftig, Dennis W. Dickson, Terrone L. Rosenberry, Malcolm A. Leissring
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer disease
Amyloid-β protein
Cathepsin D
Proteostasis
Lysosomes
Online Access:http://link.springer.com/article/10.1186/s13195-020-00649-8

Internet

http://link.springer.com/article/10.1186/s13195-020-00649-8

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