Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.

Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.

Liver fibrosis is mediated by hepatic stellate cells (HSCs), which respond to a variety of cytokine and growth factors to moderate the response to injury and create extracellular matrix at the site of injury. G-protein coupled receptor (GPCR)-mediated signaling, via endothelin-1 (ET-1) and angiotens...

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Bibliographic Details
Main Authors: Arya J Bahrami, Jagadambika J Gunaje, Brian J Hayes, Kimberly J Riehle, Heidi L Kenerson, Raymond S Yeung, April S Stempien-Otero, Jean S Campbell, William M Mahoney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4188519?pdf=render

Internet

http://europepmc.org/articles/PMC4188519?pdf=render

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