Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway

Dynamics of receptor-operated Ca2+ Currents Through TRPC Channels Controlled via the PI(4,5)P2-PLC Signaling Pathway

Transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels that carry receptor-operated Ca2+ currents (ROCs) triggered by receptor-induced, phospholipase C (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). Within the vascula...

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Bibliographic Details
Main Authors: Masayuki X Mori, Kyohei eItsuki, Hideharu eHase, Seishirou eSawamura, Tatsuki eKurokawa, Yasuo eMori, Ryuji eInoue
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Pharmacology
Subjects:
Ca2+ signaling
Smooth muscle
TRPC channels
PIP2
receptor-operated calcium current
voltage-sensing phosphatase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00022/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00022/full

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