NPM1 Mutational Status Underlines Different Biological Features in Pediatric AML

NPM1 Mutational Status Underlines Different Biological Features in Pediatric AML

Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling protein, predominantly located in the nucleolus, that regulates a multiplicity of different biological processes. NPM1 localization in the cell is finely tuned by specific signal motifs, with two tryptophan residues (Trp) being essential for the...

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Bibliographic Details
Main Authors: Claudia Tregnago, Maddalena Benetton, Davide Padrin, Katia Polato, Giulia Borella, Ambra Da Ros, Anna Marchetti, Elena Porcù, Francesca Del Bufalo, Cristina Mecucci, Franco Locatelli, Martina Pigazzi
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
Nucleophosmin, NPM1
acute myeloid leukemia
gene expression
TP53
mutation
genetic
Online Access:https://www.mdpi.com/2072-6694/13/14/3457

Internet

https://www.mdpi.com/2072-6694/13/14/3457

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