Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure

Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure

Background: Cardiac bridging integrator 1 (cBIN1) organizes transverse tubule (t-tubule) membrane calcium handling microdomains required for normal beat-to-beat contractility. cBIN1 is transcriptionally reduced in heart failure (HF). We recently found that cBIN1 pretreatment can limit HF development...

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Bibliographic Details
Main Authors: Jing Li, Sosse Agvanian, Kang Zhou, Robin M. Shaw, TingTing Hong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
heart failure
ion channel
cardiac bridging integrator 1
calcium handling
gene therapy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00708/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00708/full

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