Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques.

Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques.

Dengue virus is transmitted by Aedes mosquitoes and infects at least 100 million people every year. Progressive urbanization in Asia and South-Central America and the geographic expansion of Aedes mosquito habitats have accelerated the global spread of dengue, resulting in a continuously increasing...

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Bibliographic Details
Main Authors: Roland Züst, Hongping Dong, Xiao-Feng Li, David C Chang, Bo Zhang, Thavamalar Balakrishnan, Ying-Xiu Toh, Tao Jiang, Shi-Hua Li, Yong-Qiang Deng, Brett R Ellis, Esther M Ellis, Michael Poidinger, Francesca Zolezzi, Cheng-Feng Qin, Pei-Yong Shi, Katja Fink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3731252?pdf=render

Internet

http://europepmc.org/articles/PMC3731252?pdf=render

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