Cx43 Expression Correlates with Breast Cancer Metastasis in MDA-MB-231 Cells In Vitro, In a Mouse Xenograft Model and in Human Breast Cancer Tissues

Cx43 Expression Correlates with Breast Cancer Metastasis in MDA-MB-231 Cells In Vitro, In a Mouse Xenograft Model and in Human Breast Cancer Tissues

Connexins regulate multiple cellular functions and are considered tumor suppressors. Connexin43 (Cx43) is frequently down-regulated in breast tumors. However, Cx43 regulation during cancer onset and metastasis is complex and context-dependent. We investigated the effect of Cx43 over-expression or kn...

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Bibliographic Details
Main Authors: Jalal M. Kazan, Jamal El-Saghir, Jessica Saliba, Abdullah Shaito, Nour Jalaleddine, Layal El-Hajjar, Sara Al-Ghadban, Lamis Yehia, Kazem Zibara, Marwan El-Sabban
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
breast cancer
connexin43
metastasis
triple negative breast cancer
epithelial-to-mesenchymal transition
EMT
Online Access:https://www.mdpi.com/2072-6694/11/4/460

Internet

https://www.mdpi.com/2072-6694/11/4/460

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