Genetic regulation of gene expression and splicing during a 10-year period of human aging

Genetic regulation of gene expression and splicing during a 10-year period of human aging

Abstract Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no long-term, longitudinal characterizatio...

Full description

Bibliographic Details
Main Authors: Brunilda Balliu, Matthew Durrant, Olivia de Goede, Nathan Abell, Xin Li, Boxiang Liu, Michael J. Gloudemans, Naomi L. Cook, Kevin S. Smith, David A. Knowles, Mauro Pala, Francesco Cucca, David Schlessinger, Siddhartha Jaiswal, Chiara Sabatti, Lars Lind, Erik Ingelsson, Stephen B. Montgomery
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Genome Biology
Subjects:
Aging
Longevity
Gene expression
Alternative splicing
Gene regulation
Online Access:http://link.springer.com/article/10.1186/s13059-019-1840-y

Internet

http://link.springer.com/article/10.1186/s13059-019-1840-y

Similar Items