Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia

NUP98-NSD1-positive acute myeloid leukemia (AML) is a poor prognostic subgroup that is frequently diagnosed in pediatric cytogenetically normal AML. NUP98-NSD1-positive AML often carries additional mutations in genes including <i>FLT3, NRAS, WT1,</i> and <i>MYC</i>. The purpo...

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Bibliographic Details
Main Authors: Sagarajit Mohanty, Nidhi Jyotsana, Amit Sharma, Arnold Kloos, Razif Gabdoulline, Basem Othman, Courteney K. Lai, Renate Schottmann, Madhvi Mandhania, Johannes Schmoellerl, Florian Grebien, Euan Ramsay, Anitha Thomas, Hans-Peter Vornlocher, Arnold Ganser, Felicitas Thol, Michael Heuser
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
AML
NUP98-NSD1
NRASG12D
siRNA
liposome
Online Access:https://www.mdpi.com/2072-6694/12/10/2766

Internet

https://www.mdpi.com/2072-6694/12/10/2766

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