Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells

Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells

Abstract Background Administration of the iron chelator deferasirox (DFX) in transfusion-dependent patients occasionally results in haematopoiesis recovery by a mechanism remaining elusive. This study aimed to investigate at a molecular level a general mechanism underlying DFX beneficial effects on...

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Bibliographic Details
Main Authors: Tiziana Tataranni, Carmela Mazzoccoli, Francesca Agriesti, Luciana De Luca, Ilaria Laurenzana, Vittorio Simeon, Vitalba Ruggieri, Consiglia Pacelli, Gerardo Della Sala, Pellegrino Musto, Nazzareno Capitanio, Claudia Piccoli
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Stem Cell Research & Therapy
Subjects:
DFX
ROS
Interferon signalling
Differentiation
Online Access:http://link.springer.com/article/10.1186/s13287-019-1293-y

Internet

http://link.springer.com/article/10.1186/s13287-019-1293-y

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