BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

Abstract Background Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibrodysplasia ossificans progressiva (FOP), is a serious condition without effective treatment. Understanding of the core process of injury-induced HO is still severely limited. Methods Double-pulse thym...

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Bibliographic Details
Main Authors: Chen Kan, Na Ding, Jiazhao Yang, Zhenya Tan, Tammy L. McGuire, Haimei Lu, Keqin Zhang, Diana M. Palila Berger, John A. Kessler, Lixin Kan
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
Heterotopic ossification (HO)
Niche
Mesenchymal stem cells (MSCs)
Niche supportive cells
Niche supportive molecules
Bone morphogenetic protein (BMP)
Online Access:http://link.springer.com/article/10.1186/s13287-018-1107-7

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http://link.springer.com/article/10.1186/s13287-018-1107-7

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