Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol

Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol

Background: Cardioprotective strategies against ischemia-reperfusion injury (IRI) that remain effective in the clinical arena need to be developed. Therefore, maintained efficacy of cardioprotective strategies in the presence of drugs routinely used clinically (e.g., opiates, benzodiazepines, P2Y12...

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Bibliographic Details
Main Authors: Yang Xiao, Philippa Phelp, Qian Wang, Diane Bakker, Rianne Nederlof, Markus W. Hollmann, Coert J. Zuurbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardioprotection
animal model
infarct size
NAD+ precursor
P2Y12 antagonist
propofol
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.712478/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.712478/full

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