The DNA Glycosylase NEIL2 Suppresses <i>Fusobacterium</i>-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells

The DNA Glycosylase NEIL2 Suppresses <i>Fusobacterium</i>-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells

Colorectal cancer (CRC) is the third most prevalent cancer, while the majority (80–85%) of CRCs are sporadic and are microsatellite stable (MSS), and approximately 15–20% of them display microsatellite instability (MSI). Infection and chronic inflammation are known to induce DNA damage in host tissu...

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Bibliographic Details
Main Authors: Ibrahim M. Sayed, Anirban Chakraborty, Amer Ali Abd El-Hafeez, Aditi Sharma, Ayse Z. Sahan, Wendy Jia Men Huang, Debashis Sahoo, Pradipta Ghosh, Tapas K. Hazra, Soumita Das
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
<i>Fusobacterium nucleatum</i>
inflammation
enteroid
enteroid-derived monolayer
DNA damage
base-excision repair
Online Access:https://www.mdpi.com/2073-4409/9/9/1980

Internet

https://www.mdpi.com/2073-4409/9/9/1980

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