Rescue of Motoneurons from Axotomy-Induced Cell Death by Polymer Encapsulated Cells Genetically Engineered to Release CNTF

The neurodegenerative disease amyotrophic lateral sclerosis (ALS) results from the progressive loss of motoneurons, leading to death in a few years. Ciliary neurotrophic factor (CNTF), which decreases naturally occurring and axotomy-induced cell death, may result in slowing of motoneuron loss and ha...

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Bibliographic Details
Main Authors: S.A. Tan, N. Déglon, A.D. Zurn, E.E. Baetge, B. Bamber, A.C. Kato, P. Aebischer
Format: Article
Language:English
Published: SAGE Publishing 1996-09-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979600500507