Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response

Genetic and Epigenetic Biomarkers of Immune Checkpoint Blockade Response

Checkpoint inhibitor therapy constitutes a promising cancer treatment strategy that targets the immune checkpoints to re-activate silenced T cell cytotoxicity. In recent pivotal trials, immune checkpoint blockade (ICB) demonstrated durable responses and acceptable toxicity, resulting in the regulato...

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Bibliographic Details
Main Authors: Qingyang Xiao, André Nobre, Pilar Piñeiro, Miguel-Ángel Berciano-Guerrero, Emilio Alba, Manuel Cobo, Volker M. Lauschke, Isabel Barragán
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Journal of Clinical Medicine
Subjects:
immunotherapy
predictor
resistance
epigenetics
stroma
melanoma
non-small-cell lung cancer
Online Access:https://www.mdpi.com/2077-0383/9/1/286

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https://www.mdpi.com/2077-0383/9/1/286

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