Ubiquitin-Specific Peptidase USP22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1

Ubiquitin-Specific Peptidase USP22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1

Background/Aims: The ubiquitin-specific peptidase USP22 mediates various cellular and organismal processes, such as cell growth, apoptosis, and tumor malignancy. However, the molecular mechanisms that regulate USP22 activity remain poorly understood. Here we identify STAT3 as a new USP22 interactor....

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Bibliographic Details
Main Authors: Ning Ao, Yanyan Liu, Hailiang Feng, Xiaocui Bian, Zhanwen Li, Bei Gu, Xiaomei Zhao, Yuqin Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
STAT3
USP22
SIRT1
Deubiquitinating
Acetylation
Online Access:http://www.karger.com/Article/FullText/362964

Internet

http://www.karger.com/Article/FullText/362964

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