The degree of astrocyte activation is predictive of the incubation time to prion disease

Abstract In neurodegenerative diseases including Alzheimer’s, Parkinson’s and prion diseases, astrocytes acquire disease-associated reactive phenotypes. With growing appreciation of their role in chronic neurodegeneration, the questions whether astrocytes lose their ability to perform homeostatic fu...

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Bibliographic Details
Main Authors: Natallia Makarava, Olga Mychko, Jennifer Chen-Yu Chang, Kara Molesworth, Ilia V. Baskakov
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-021-01192-9