ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion

ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion

Although conventional radiotherapy promotes the migration/invasion of cancer stem cells (CSCs) under normoxia, carbon ion (C-ion) irradiation actually decreases these processes. Unraveling the mechanisms of this discrepancy, particularly under the hypoxic conditions that pertain in niches where CSCs...

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Bibliographic Details
Main Authors: Anne-Sophie Wozny, Guillaume Vares, Gersende Alphonse, Alexandra Lauret, Caterina Monini, Nicolas Magné, Charlotte Cuerq, Akira Fujimori, Jean-Claude Monboisse, Michael Beuve, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
X-ray irradiation
carbon ion irradiation
reactive oxygen species
cancer stem cells
hypoxia
metastases
invasion/migration
Online Access:https://www.mdpi.com/2072-6694/11/4/468

Internet

https://www.mdpi.com/2072-6694/11/4/468

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