The Role of Apelin on the Alleviative Effect of Angiotensin Receptor Blocker in Unilateral Ureteral Obstruction-Induced Renal Fibrosis

The Role of Apelin on the Alleviative Effect of Angiotensin Receptor Blocker in Unilateral Ureteral Obstruction-Induced Renal Fibrosis

Background: Apelin is a selective endogenous ligand of the APJ receptor, which genetically has closest identity to the angiotensin II type 1 receptor (AT-1). The effects of the apelin/APJ system on renal fibrosis still remain unclear. Methods: We examined the effects of the apelin/APJ system on rena...

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Bibliographic Details
Main Authors: Masashi Nishida, Yasuko Okumura, Tatsujiro Oka, Kentaro Toiyama, Seiichiro Ozawa, Toshiyuki Itoi, Kenji Hamaoka
Format: Article
Language:English
Published: Karger Publishers 2012-03-01
Series:Nephron Extra
Subjects:
Apelin
APJ receptor
Angiotensin receptor blocker
Nitric oxide
Renal fibrosis
Unilateral ureteral obstruction
Online Access:http://www.karger.com/Article/FullText/337091

Internet

http://www.karger.com/Article/FullText/337091

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