Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice.

Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice.

Valvular disease is common in patients with Marfan syndrome and can lead to cardiomyopathy. However, some patients develop cardiomyopathy in the absence of hemodynamically significant valve dysfunction, suggesting alternative mechanisms of disease progression. Disruption of LDL receptor-related prot...

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Bibliographic Details
Main Authors: Joshua E Basford, Sheryl Koch, Ahmad Anjak, Vivek P Singh, Eric G Krause, Nathan Robbins, Neal L Weintraub, David Y Hui, Jack Rubinstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3843717?pdf=render

Internet

http://europepmc.org/articles/PMC3843717?pdf=render

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