Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

The Göttingen Minipig is gaining ground as nonrodent species in safety testing of drugs for pediatric indications. Due to developmental changes in pharmacokinetics and pharmacodynamics, physiologically based pharmacokinetic (PBPK) models are built to better predict drug exposure in children and to a...

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Bibliographic Details
Main Authors: Laura Buyssens, Laura De Clerck, Wim Schelstraete, Maarten Dhaenens, Dieter Deforce, Miriam Ayuso, Chris Van Ginneken, Steven Van Cruchten
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
CYP
protein abundance
ontogeny
Göttingen Minipig
pediatrics
mass spectrometry
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.665644/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.665644/full

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