Oxidation derivative of (-)-epigallocatechin-3-gallate (EGCG) inhibits RANKL-induced osteoclastogenesis by suppressing RANK signaling pathways in RAW 264.7 cells

Oxidation derivative of (-)-epigallocatechin-3-gallate (EGCG) inhibits RANKL-induced osteoclastogenesis by suppressing RANK signaling pathways in RAW 264.7 cells

Tea consumption has positive effects on the skeletal system and prevents postmenopausal osteoporosis, mainly by inhibiting osteoclastogenesis. In green tea, (-)-epigallocatechin-3-gallate (EGCG) is the most abundant and active compound and has been shown to inhibit RANKL-induced osteoclast formation...

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Bibliographic Details
Main Authors: Huanhuan Xu, Titi Liu, Jin Li, Jing Xu, Fei Chen, Lihong Hu, Banglei Zhang, Chengting Zi, Xuanjun Wang, Jun Sheng
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
EGCG
Oxidation derivative
Osteoclastogenesis
NFATc1
c-Fos
RANK signaling pathways
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219323893

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http://www.sciencedirect.com/science/article/pii/S0753332219323893

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