miR-135a Reduces Osteosarcoma Pulmonary Metastasis by Targeting Both BMI1 and KLF4

Because of the modest response rate after surgery and chemotherapy, treatment of osteosarcoma (OS) remains challenging due to tumor recurrence and metastasis. miR-135a has been reported to act as an anticarcinogenic regulator of several cancers. However, its expression and function in osteosarcoma r...

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Bibliographic Details
Main Authors: Chenglong Chen, Xingjia Mao, Caitong Cheng, Yurui Jiao, Yi Zhou, Tingting Ren, Zhuangzhuang Wu, Zhi Lv, Xiaojuan Sun, Wei Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.620295/full