Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in Salmonella typhimurium

Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in Salmonella typhimurium

Bacterial resistance to antibiotics is a major concern worldwide, leading to an extensive search for alternative drugs. Promising candidates are antimicrobial peptides (AMPs), innate immunity molecules, shown to be highly efficient against multidrug resistant bacteria. Therefore, it is essential to...

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Bibliographic Details
Main Authors: Gal Kapach, Reut Nuri, Christiane Schmidt, Adi Danin, Shir Ferrera, Alon Savidor, Roman G. Gerlach, Yechiel Shai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial peptide (AMPs)
bacterial resistance
AcrAB-TolC
ramR
Skp
periplasm
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00189/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00189/full

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