Compensatory role of the Nrf2–ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity

Compensatory role of the Nrf2–ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity

Oxidative stress and the ubiquitin–proteasome system play a key role in the pathogenesis of Parkinson disease. Although the herbicide paraquat is an environmental factor that is involved in the etiology of Parkinson disease, the role of 26S proteasome in paraquat toxicity remains to be determined. U...

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Bibliographic Details
Main Authors: Yasuhiko Izumi, Noriyuki Yamamoto, Sayaka Matsushima, Takamori Yamamoto, Yuki Takada-Takatori, Akinori Akaike, Toshiaki Kume
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Nrf2–ARE pathway
Oxidative stress
Paraquat
Parkinson disease
Proteasome activity
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002029

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http://www.sciencedirect.com/science/article/pii/S1347861315002029

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