Repeated Blockade of NMDA Receptors during Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex

Repeated Blockade of NMDA Receptors during Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex

Adolescence is of particular significance to schizophrenia, since psychosis onset typically occurs in this critical period. Based on the N-methyl-D-aspartate (NMDA) receptor hypofunction hypothesis of schizophrenia, in this study, we investigated whether and how repeated NMDA receptor blockade durin...

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Bibliographic Details
Main Authors: Jitao eLi, Yunai eSu, Hongli eWang, Yingying eZhao, Xuemei eLiao, Xiao-Dong eWang, Tianmei eSi
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Interneurons
Prefrontal Cortex
Reversal Learning
adolescence
rat
MK-801
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00017/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00017/full

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