Idebenone Protects against Spontaneous Chronic Murine Colitis by Alleviating Endoplasmic Reticulum Stress and Inflammatory Response

Idebenone Protects against Spontaneous Chronic Murine Colitis by Alleviating Endoplasmic Reticulum Stress and Inflammatory Response

Endoplasmic reticulum (ER) stress in intestinal secretory goblet cells has been linked to the development of ulcerative colitis (UC). Emerging evidence suggests that the short chain quinone drug idebenone displays anti-inflammatory activity in addition to its potent antioxidant and mitochondrial ele...

Full description

Bibliographic Details
Main Authors: Sonia Shastri, Tanvi Shinde, Agampodi Promoda Perera, Nuri Gueven, Rajaraman Eri
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomedicines
Subjects:
chronic colitis
endoplasmic reticulum stress
idebenone
mucin
pro-inflammatory cytokines
<i>Winnie</i>
Online Access:https://www.mdpi.com/2227-9059/8/10/384

Internet

https://www.mdpi.com/2227-9059/8/10/384

Similar Items