Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury

Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury

Traumatic brain injury has a poorer prognosis in elderly patients, possibly because of the enhanced inflammatory response characteristic of advanced age, known as “inflammaging.” Recently, reduced activation of the TANK-Binding-Kinase 1 (Tbk1) pathway has been linked to age-associated neurodegenerat...

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Bibliographic Details
Main Authors: Rida Rehman, Lilla Tar, Adeyemi Jubril Olamide, Zhenghui Li, Jan Kassubek, Tobias Böckers, Jochen Weishaupt, Albert Ludolph, Diana Wiesner, Francesco Roselli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
TBK1
microglia
traumatic brain injury
amlexanox
neuroinflammation
stab wound injury
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.684171/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.684171/full

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