Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1.
The humoral response to fungal and Gram-positive infections is regulated by the serpin-family inhibitor, Necrotic. Following immune-challenge, a proteolytic cascade is activated which signals through the Toll receptor. Toll activation results in a range of antibiotic peptides being synthesised in th...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-06-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC2694266?pdf=render |