Genome-wide Anaplasma phagocytophilum AnkA-DNA interactions are enriched in intergenic regions and gene promoters and correlate with infection-induced differential gene expression.

Genome-wide Anaplasma phagocytophilum AnkA-DNA interactions are enriched in intergenic regions and gene promoters and correlate with infection-induced differential gene expression.

Anaplasma phagocytophilum, an obligate intracellular prokaryote, infects neutrophils and alters cardinal functions via reprogrammed transcription. Large contiguous regions of neutrophil chromosomes are differentially expressed during infection. Secreted A. phagocytophilum effector AnkA transits into...

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Bibliographic Details
Main Authors: J Stephen Dumler, Sara H. Sinclair, Valeria Pappas-Brown, Amol Shetty
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Anaplasma phagocytophilum
Matrix Attachment Regions
Nuclear Lamina
cellular reprogramming
ANKA
MHC locus
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00097/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00097/full

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