Reelin Is Required for Maintenance of Granule Cell Lamination in the Healthy and Epileptic Hippocampus

One characteristic feature of mesial temporal lobe epilepsy is granule cell dispersion (GCD), a pathological widening of the granule cell layer in the dentate gyrus. The loss of the extracellular matrix protein Reelin, an important positional cue for neurons, correlates with GCD formation in MTLE pa...

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Bibliographic Details
Main Authors: Catarina Orcinha, Antje Kilias, Enya Paschen, Marie Follo, Carola A. Haas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.730811/full