GABAergic Control of Nigrostriatal and Mesolimbic Dopamine in the Rat Brain

GABAergic Control of Nigrostriatal and Mesolimbic Dopamine in the Rat Brain

Purpose: The present study assessed the effects of the GABAA receptor (R) agonist muscimol (MUS), and the GABAAR antagonist bicuculline (BIC) on neocortical and subcortical radioligand binding to dopamine D2/3Rs in relation to motor and exploratory behaviors in the rat.Methods: D2/3R binding was mea...

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Bibliographic Details
Main Authors: Susanne Nikolaus, Hans-Jörg Wittsack, Markus Beu, Christina Antke, Maria A. De Souza Silva, Frijthof Wickrath, Anja Müller-Lutz, Joseph P. Huston, Gerald Antoch, Hans-Wilhelm Müller, Hubertus Hautzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
D2/3 receptor
[123I]IBZM
GABAA receptor
muscimol
bicuculline
Online Access:http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00038/full

Internet

http://journal.frontiersin.org/article/10.3389/fnbeh.2018.00038/full

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