Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus

Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus

Cytotoxic T lymphocytes (CTLs) represent key immune effectors of the host response against chronic viruses, due to their cytotoxic response to virus-infected cells. In response to this selection pressure, viruses may accumulate escape mutations that evade CTL-mediated control. To study the emergence...

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Bibliographic Details
Main Authors: Mark Smyth, Kseniya Khamina, Alexandra Popa, Venugopal Gudipati, Benedikt Agerer, Alexander Lercher, Lindsay Kosack, Lukas Endler, Hatoon Baazim, Csilla Viczenczova, Johannes B. Huppa, Andreas Bergthaler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
viral infection
lymphocytic choriomeningitis (LCMV)
CD8 T cell
immune evasion
mouse model
CTL escape mutation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.638485/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.638485/full

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