IL-1β As Mediator of Resolution That Reprograms Human Peripheral Monocytes toward a Suppressive Phenotype

IL-1β As Mediator of Resolution That Reprograms Human Peripheral Monocytes toward a Suppressive Phenotype

During infection pathogen-associated molecular patterns activate immune cells to initiate a cascade of reactions leading to inflammation and the activation of the adaptive immune response culminating in the elimination of foreign pathogens. However, shortly after activation of the host defense machi...

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Bibliographic Details
Main Authors: Katharina Giesbrecht, Mariel-Esther Eberle, Sabine J. Wölfle, Delal Sahin, Aline Sähr, Valerie Oberhardt, Zach Menne, Konrad A. Bode, Klaus Heeg, Dagmar Hildebrand
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
resolution of inflammation
tolerogenic factors
signal transducer and activator of transcription 3
indoleamine 2,3-dioxygenase
PD-L1
adenosine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00899/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.00899/full

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