Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics

Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics

Abstract Hijacking of host metabolic status by a pathogen for its regulated dissemination from the host is prerequisite for the propagation of infection. M. tuberculosis secretes an NAD+-glycohydrolase, TNT, to induce host necroptosis by hydrolyzing Nicotinamide adenine dinucleotide (NAD+). Herein,...

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Bibliographic Details
Main Authors: Ayushi Chaurasiya, Swati Garg, Ashish Khanna, Chintam Narayana, Ved Prakash Dwivedi, Nishant Joshi, Zill e Anam, Niharika Singh, Jhalak Singhal, Shikha Kaushik, Amandeep Kaur Kahlon, Pallavi Srivastava, Manisha Marothia, Mukesh Kumar, Santosh Kumar, Geeta Kumari, Akshay Munjal, Sonal Gupta, Preeti Singh, Soumya Pati, Gobardhan Das, Ram Sagar, Anand Ranganathan, Shailja Singh
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-020-00366-z

Internet

https://doi.org/10.1038/s41420-020-00366-z

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