Anti-Carbamylated LL37 Antibodies Promote Pathogenic Bone Resorption in Rheumatoid Arthritis

Anti-Carbamylated LL37 Antibodies Promote Pathogenic Bone Resorption in Rheumatoid Arthritis

ObjectiveAntibodies against carbamylated proteins (anti-CarP) are associated with poor prognosis and the development of bone erosions in rheumatoid arthritis (RA). RA neutrophils externalize modified autoantigens through the formation of neutrophil extracellular traps (NETs). Increased levels of the...

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Bibliographic Details
Main Authors: Liam J. O’Neil, Christopher B. Oliveira, Donavon Sandoval-Heglund, Ana Barrera-Vargas, Javier Merayo-Chalico, Eduardo Aguirre-Aguilar, Mariana J. Kaplan, Carmelo Carmona-Rivera
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
LL-37
carbamylation
neutrophils
rheumatoid arthritis
NETs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.715997/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.715997/full

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