The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1

The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1

Summary: Voltage-gated calcium channel auxiliary α2δ subunits are important for channel trafficking and function. Here, we compare the effects of α2δ-1 and an α2δ-like protein called Cachd1 on neuronal N-type (CaV2.2) channels, which are important in neurotransmission. Previous structural studies sh...

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Bibliographic Details
Main Authors: Shehrazade Dahimene, Karen M. Page, Ivan Kadurin, Laurent Ferron, Dominique Y. Ho, Gareth T. Powell, Wendy S. Pratt, Stephen W. Wilson, Annette C. Dolphin
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316097

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http://www.sciencedirect.com/science/article/pii/S2211124718316097

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