In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome.

Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal models using host-specific CMVs. Infection of rhesus macaques (RM) with rhesus CMV (RhCMV) has been established as a repr...

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Main Authors: Husam Taher, Eisa Mahyari, Craig Kreklywich, Luke S Uebelhoer, Matthew R McArdle, Matilda J Moström, Amruta Bhusari, Michael Nekorchuk, Xiaofei E, Travis Whitmer, Elizabeth A Scheef, Lesli M Sprehe, Dawn L Roberts, Colette M Hughes, Kerianne A Jackson, Andrea N Selseth, Abigail B Ventura, Hillary C Cleveland-Rubeor, Yujuan Yue, Kimberli A Schmidt, Jason Shao, Paul T Edlefsen, Jeremy Smedley, Timothy F Kowalik, Richard J Stanton, Michael K Axthelm, Jacob D Estes, Scott G Hansen, Amitinder Kaur, Peter A Barry, Benjamin N Bimber, Louis J Picker, Daniel N Streblow, Klaus Früh, Daniel Malouli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008666