RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.

RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.

Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus exerting an inhibitory effect on the Raf-MEK-Erk pa...

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Bibliographic Details
Main Authors: Ila Datar, Jingwei Feng, Xiaoliang Qiu, John Lewandowski, Miranda Yeung, Gang Ren, Shweta Aras, Fahd Al-Mulla, Hongjuan Cui, Robert Trumbly, Sri Krishna Chaitanya Arudra, Luis E De Las Casas, Ivana de la Serna, Milad S Bitar, Kam C Yeung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4550449?pdf=render

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http://europepmc.org/articles/PMC4550449?pdf=render

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