Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission

Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission

Abstract Background Alzheimer’s disease (AD) is the most common form of age-related neurodegenerative diseases. Cerebral deposition of Aβ peptides, especially Aβ42, is considered the major neuropathological hallmark of AD and the putative cause of AD-related neurotoxicity. Aβ peptides are produced b...

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Bibliographic Details
Main Authors: Tugce Munise Satir, Lotta Agholme, Anna Karlsson, Mattias Karlsson, Paul Karila, Sebastian Illes, Petra Bergström, Henrik Zetterberg
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
BACE inhibition
Synaptic transmission
Alzheimer’s disease
Amyloid beta
Beta-secretase
Online Access:http://link.springer.com/article/10.1186/s13195-020-00635-0

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http://link.springer.com/article/10.1186/s13195-020-00635-0

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