Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor.

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor.

Azole antifungal ketoconazole (KET) was demonstrated to activate aryl hydrocarbon receptor (AhR). Since clinically used KET is a racemic mixture of two cis-enantiomers (2R,4S)-(+)-KET and (2S,4R)-(-)-KET, we examined the effects of KET enantiomers on AhR signaling pathway. (+)-KET dose-dependently a...

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Bibliographic Details
Main Authors: Aneta Novotna, Martina Korhonova, Iveta Bartonkova, Anatoly A Soshilov, Michael S Denison, Katerina Bogdanova, Milan Kolar, Petr Bednar, Zdenek Dvorak
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4084896?pdf=render

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http://europepmc.org/articles/PMC4084896?pdf=render

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