Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor

Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor

Abstract Rhabdoid tumor (RT) is a pediatric cancer characterized by the inactivation of SMARCB1, a subunit of the SWI/SNF chromatin remodeling complex. Although this deletion is the known oncogenic driver, there are limited effective therapeutic options for these patients. Here we use unbiased scree...

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Bibliographic Details
Main Authors: Maggie H Chasse, Benjamin K Johnson, Elissa A Boguslawski, Katie M Sorensen, Jessica E Rosien, Min H Kang, C Patrick Reynolds, Lyong Heo, Zachary B Madaj, Ian Beddows, Gabrielle E Foxa, Susan M Kitchen‐Goosen, Bart O Williams, Timothy J Triche Jr, Patrick J Grohar
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:EMBO Molecular Medicine
Subjects:
EC8042
epigenetics
mithramycin
pediatric cancer
SWI/SNF
Online Access:https://doi.org/10.15252/emmm.202012640

Internet

https://doi.org/10.15252/emmm.202012640

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