Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy

Abstract Background While the etiology remains elusive, macrophages and T cells in peripheral nerves are considered as effector cells mediating autoimmune peripheral neuropathy (APN), such as Guillain-Barre syndrome. By recognizing both pathogen-associated molecular patterns (PAMPs) and damage-assoc...

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Bibliographic Details
Main Authors: Oladayo Oladiran, Xiang Qun Shi, Mu Yang, Sylvie Fournier, Ji Zhang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Neuroinflammation
Subjects:
Autoimmunity
Inflammation
Demyelination
Macrophages
CD8+ T cells
TLR4
Online Access:https://doi.org/10.1186/s12974-021-02126-x

Internet

https://doi.org/10.1186/s12974-021-02126-x

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