A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer.

A bi-stable feedback loop between GDNF, EGR1, and ERα contribute to endocrine resistant breast cancer.

Discovering regulatory interactions between genes that specify the behavioral properties of cells remains an important challenge. We used the dynamics of transcriptional changes resolved by PRO-seq to identify a regulatory network responsible for endocrine resistance in breast cancer. We show that G...

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Bibliographic Details
Main Authors: Sachi Horibata, Edward J Rice, Hui Zheng, Chinatsu Mukai, Tinyi Chu, Brooke A Marks, Scott A Coonrod, Charles G Danko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5882141?pdf=render

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http://europepmc.org/articles/PMC5882141?pdf=render

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