Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma

Combinatorial Nanomedicine Made of Squalenoyl-Gemcitabine and Edelfosine for the Treatment of Osteosarcoma

Due to chemoresistance and a high propensity to form lung metastasis, survival rates in pediatric osteosarcoma (OS) are poor. With the aim to improve anticancer activity in pediatric OS, a multidrug nanomedicine was designed using the alkyl-lysophospholipid edelfosine (EF) co-assembled with squaleno...

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Bibliographic Details
Main Authors: Carlos Rodríguez-Nogales, Haritz Moreno, Carolina Zandueta, Didier Desmaële, Fernando Lecanda, Patrick Couvreur, María J. Blanco-Prieto
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
osteosarcoma
chemotherapy
pediatric cancer
metastasis
nanomedicine
gemcitabine
Online Access:https://www.mdpi.com/2072-6694/12/7/1895

Internet

https://www.mdpi.com/2072-6694/12/7/1895

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