Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1

Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1

Cancer immunotherapy is revolutionizing oncology and has emerged as a promising strategy for the treatment of multiple cancers. Indoleamine 2,3-dioxygenase 1 (IDO1), an immune checkpoint, plays an important role in tumor immune escape through the regulation of multiple immune cells and has been rega...

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Bibliographic Details
Main Authors: Mingxing Hu, Weilin Zhou, Yijie Wang, Dongping Yao, Tinghong Ye, Yuqin Yao, Bin Chen, Gongping Liu, Xifei Yang, Wei Wang, Yongmei Xie
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
IDO1
PROTAC
Protein degradation
Ubiquitin proteasome system
Tumor immune escape
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519314844

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http://www.sciencedirect.com/science/article/pii/S2211383519314844

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