Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

Foam cells are specialized lipid-loaded macrophages derived from monocytes and are a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a major lipid component of the plasma membrane with a broad spectrum of proinflammatory activities and plays a key role in athero...

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Bibliographic Details
Main Authors: Rafael Corrêa, Luís Felipe Fonseca Silva, Dalila Juliana Silva Ribeiro, Raquel das Neves Almeida, Igor de Oliveira Santos, Luís Henrique Corrêa, Lívia Pimentel de Sant'Ana, Leonardo Santos Assunção, Patrícia T. Bozza, Kelly Grace Magalhães
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
lysophosphatidylcholine
foam cells
lipid droplet
inflammasome
NLRP3
atherosclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02927/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02927/full

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