Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II

Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II

Background: Tyrosine kinase inhibitors (TKIs) have dramatically improved cancer treatment but are known to cause cardiotoxicity. The pathophysiological consequences of TKI therapy are likely to manifest across different cell types of the heart, yet there is little understanding of the differential a...

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Bibliographic Details
Main Authors: Calum J. McMullen, Susan Chalmers, Rachel Wood, Margaret R. Cunningham, Susan Currie
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
sunitinib
cardiac fibroblast
CaMKII
cardiotoxicity
imatinib
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.630480/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2020.630480/full

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